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In healthy adults the total concentration sits around 200 to 600 pmol/L, but the upper reference limit varies by laboratory and by analytical platform

+ Methionine It assists in the breakdown of fats and thereby prevents the build-up of fat in the arteries, as well as assisting with digestive system and removing heavy metals from the body since it can be converted to cytosine, which is a precursor to glutathione, which is of prime importance in detoxifying the liver

For severe ankle injuries, chronic instability, or post-surgical recovery, the combination approach warrants serious consideration

This theoretical advantage has led some practitioners to favour methylcobalamin for certain patients