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This adaptation, driven by receptor desensitization, may require higher doses or alternative treatments ([web:4])

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The overall safety profile of 2G oral semaglutide was consistent with the established safety profile of 1G oral semaglutide [36] and with that of the GLP-1RA class [37]

[DOI] [PubMed] [Google Scholar] 11.Furst DE, Munster T