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Absence of Human Data: The most critical gap remains the absence of large, well-designed human clinical trials providing conclusive evidence of weight loss

qRT-PCR analysis revealed the marked upregulation of CDKN2A (encoding p16) , CDKN1A (encoding p21) , interleukin-8 ( IL-8) , and matrix metalloproteinase ( MMP)-12 expression (Figure 1D)

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Also, water has to be absorbed through your digestive tract, so it takes time for water to restore your fluid balance