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Inhibition of Complex 1 by Metformin and Metabolic Reprogramming in Cancer Cells A growing body of epidemiological and clinical studies reported that metformin reduces cancer risk in patients with type 2 diabetes and improves survival outcome of cancer patients with breast, ovarian, liver and colorectal tumors (51)

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Statements Author contributions YL: Writing original draft, Formal Analysis, Visualization

PMCID: PMC13080939

Acetyl-L-carnitine (ALCA) fed to aged rats was shown to reverse age-related declines in tissue L-carnitine levels and also reversed a number of age-related changes in liver mitochondrial function