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This is a theoretical risk, not a demonstrated one, and it should factor into who avoids this stack (see below)

Prolonged UV exposure accelerates aging, leading to fine lines, dark spots, and uneven texture

Shaha C, Suri A, Talwar GP (1990) Induction of infertility in female rats after active immunization with 24 kD antigens from rat testes

P., Pham, H

The professional consensus in dermatology is: There is reasonable evidence for short-term brightening effects and antioxidant benefits at the cellular level Long-term safety and efficacy data are insufficient to make strong, universal clinical recommendations Medical supervision, appropriate dosing, and quality-controlled formulations are the essential safeguards that separate beneficial outcomes from adverse events WebMD's guide to glutathione provides a useful overview of potential risks and interactions for further reading