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Bourdas DI, Souglis A, Zacharakis ED, Geladas ND, Travlos AK (2021) Meta-analysis of carbohydrate solution intake during prolonged exercise in adults: from the last 45+ years perspective

(2015) the most directly relevant published study on this question measured histamine and other biogenic amine concentrations across multiple coffee preparations and found that specialty-grade coffee produced beverages with either undetectable or very low histamine concentrations across most brewing methods tested, with meaningful variation between methods [ 2 ]

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Use proper technique: Rotate injection sites and follow guidelines to ensure comfort and effectiveness

Maynard, C