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Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and GLP-1/GIP dual agonists, collectively referred to as GLP-1-based medications, have transformed the treatment landscape for obesity and cardiometabolic disease

Lose fat quickly, and estrogen levels shift

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Some peptides can be naturally derived from sources such as plants, milk, or silk, while others are synthetically produced in labs

Oral semaglutide should be considered as second-line therapy after metformin, particularly when weight is an issue and possibly in those at higher cardiovascular risk