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Lipid Metabolism & 3-AR Mechanism Heffernan et al., Endocrinology (2001) Heffernan and colleagues investigated the lipolytic effects of chronic AOD-9604 treatment using two complementary mouse models: diet-induced obese C57BL/6J mice and beta3 adrenergic receptor (3-AR) knockout mice

High-protein diets tend to work best because protein preserves lean mass while supporting fat loss

This nutrient is required for fat metabolism and injecting more of this nutrient causes fat loss are different claims, and only the first is supported

These studies have contributed to understanding the potential role of NNMT in metabolic disorders

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