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For weight management, the FDA-approved options are Wegovy (semaglutide) and Zepbound (tirzepatide).

Interventional studies have shown that pharmacological agents targeting metabolic and hemodynamic stress, such as SGLT2 inhibitors, GLP-1 receptor agonists, and renin-angiotensin system blockers, can partially restore plasma and urinary acylcarnitine levels

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While most people lose weight on Mounjaro, studies show about 5-10% of participants are non-responders who lose less than 5% body weight 3

The evidence in humans is less dramatic but still positive