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In orthopedics, postmenopausal osteoporosis (PMOP) is associated with a significant decline in the diversity and abundance of intestinal microbial communities in a clinical study enrolling 106 individuals, while bone loss was positively correlated with the decrease in genera Allisonella , Klebsiella , and Megasphaera ( This subtle link between intestinal ecology and the bone microenvironment is defined as the gutbone axis ( Therefore, this review focused on orthopedic diseases, particularly osteoporosis

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