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It is buried in the same orthosteric site of the ghrelin receptor and displays comparable potency for receptor activation (Fig
PMID: 2892969
Markers of protein oxidation (protein carbonyl glutamic [GSA] and aminoadipic [AASA] semialdehydes), glycoxidation (carboxyethyl-lysine [CEL], carboxymethyl-lysine [CML] and carboxymethyl-cysteine [CMC]), lipoxidation (malondialdehyde-lysine [MDAL]) and mitochondrial stress (2-succinyl-cysteine [2SC]) were identified as trifluoroacetic acid methyl ester derivatives in acid hydrolyzed delipidated and reduced plasma protein samples by GC/MS
This effect is most pronounced after initiation and may diminish somewhat with chronic use
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