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Some people have reported worsening suicidal ideation, and given the known association between bariatric surgery and suicidality, these reports should be taken seriously and discussed with patients while we await further research on this potential connection

Do not inject the water directly onto the lyophilized powder

This single reaction sits at the intersection of two critical metabolic axes: The folate cycle axis: 5-MTHF is the methyl donor that MTR uses to regenerate methionine from homocysteine, simultaneously regenerating tetrahydrofolate (THF) that feeds back into one-carbon metabolism for nucleotide synthesis (thymidylate and purine biosynthesis)

While we cannot disregard the possibility of some remaining effects of relaxation time differentials, we note that our results are metabolite-specific, while systematic between-group differences in relaxation times would likely impact all metabolite concentrations equally

For years, this treatment was available only as a weekly injection