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Chronic kidney disease (CKD), particularly in later stages, is a recognized cause of hypercobalaminemia

Estimates suggest only about 50% or less is absorbed by the body

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Because NNMT occupies a central position within nicotinamide methylation pathways, it has become an important target for investigations involving enzyme regulation, methyl-donor utilization, cofactor-associated signaling networks, and methyltransferase pharmacology

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