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Therefore, it remains unclear whether the reduction of steatosis observed in animal and human trials in response to treatment with GLP-1R agonists results from direct activation of hepatic GLP-1R or the indirect impact such as weight loss, increased insulin sensitivity, brain-liver signals such as brain leptin 51 , or other hormonal signals that these agonists might trigger 14

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Healthcare professionals performing colonoscopy should routinely enquire about GLP-1 receptor agonist use during pre-procedure assessment

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Methionine is an essential amino acid that plays a vital role in removing fat from your body