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NAD levels decline with age, which has sparked a surge of interest in NAD IV drips, NAD injections, and oral precursors such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN)

Drmic et al., Counteraction of perforated cecum lesions in rats: Effects of pentadecapeptide BPC 157, L-NAME and L-arginine, World J

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Depression in withdrawal may become protracted (see section on protracted symptoms) and if it does not lift within a few weeks and is unresponsive to simple reassurance and encouragement, it is worth seeking a medical opinion and possibly taking an antidepressant drug (see section on adjuvant medication)