Sample size, patient characteristics (age, gender, BMI, diabetes duration)
This is often done in phase 1 clinical trials during new drug development
NICE guidance requires that Saxenda be prescribed only within specialist NHS weight management services, and combining it with bupropion requires individualised medical assessment, structured monitoring of blood pressure, heart rate, mental health status, and regular follow-up appointments to ensure treatment safety
The therapeutic benefits, particularly in treating fatty liver disease, often outweigh potential risks when patients are properly monitored and maintain adequate hydration during treatment
Compared with other antidiabetic or weight-reducing treatments, GLP-1 receptor agonists produced increased gonadotropins and sex hormone-binding globulin and improved erectile function, with serum androgen levels comparable to or exceeding those of other agents