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Noteworthy, a limitation of the use of dynamic PDU is the contraindication of PGE1 administration in patients with recent CV or cerebrovascular events and with unstable hemodynamic conditions, and its careful administration in patients with risk of arterial hypotension, such as those in treatment with vasodilatory medications, particularly medications increasing NO production [42]

Supplementation is given by parenteral preparations of cyanocobalamin @ 2- 5 g /kg

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Combining biomarker and imaging endpoints could determine whether combination therapy enhances plaque stabilization and cardiovascular protection

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