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The effect of long-term ketosis/carbohydrate restriction on cognitive function in adults is unclear [67]

Unlike SGLT2 inhibitors (another class of diabetes medications), semaglutide does not have diuretic properties that would directly increase urine output

If Eli Lilly files for FDA approval in 2026 and the process runs smoothly, MHRA authorisation could follow by late 2027 or early 2028

When the body produces insufficient digestive enzymes, a condition known as exocrine pancreatic insufficiency may develop, leading to malabsorption, bloating, diarrhoea, and nutritional deficiencies

Microglia and macrophages also directly mediate tissue injury through the release of pro-inflammatory cytokines (e.g., IL-1, IL-6, TNF-) and reactive mediators that contribute to oligodendrocyte and axonal damage (123)