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Without intervention, roughly 15 to 30% of people with prediabetes develop type 2 diabetes within five years

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showed that changes in SDC-1 mechanical tension generate a tension gradient in SDC-1 under fluid shear force, with SDC-1 interacting differently with the cytoskeleton depending on substrate stiffness, affecting integrin-mediated signaling and focal adhesion formation [49]

This mechanism leads to significant weight loss over time, typically over several months