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People are used to taking pills, he said

Neuropharmacology (2015) 89:30817

It appears at least at mouse islet GLP-1R that pGLP-1 would act with classical incretin function to promote insulin release, although whether this is the primary function in the platypus remains to be proven

That might mean focusing more on lifestyle changes, switching medications, or considering bariatric surgery. For some patients, surgical options such as sleeve gastrectomy may be appropriate, particularly if they want a more durable intervention

doi:10.1056/nejmoa2511774 19.A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight (TRIUMPH-1)