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Adequate selenium intake is mandatory for the normal function of thyrocytes, and selenium deficiency is associated with the decreased synthesis of thyroid hormones (191), increased thyroid volume, and increased number of thyroid nodules (182, 192)

While those results are encouraging, direct comparisons between Retatrutide and tirzepatide should be interpreted carefully because the medications have been studied in different clinical trials with different patient populations, treatment durations, and study designs

Glucose-regulated anaplerosis in beta cells

Clogged arteries (coronary artery disease)

Both face absorption challenges