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In certain embodiments, any controlled-release otic formulation described herein increases the exposure time of an active agent and decreases the C max in otic fluids (e.g., endolymph and/or perilymph) by about 40%, about 30%, about 20%, or about 10%, compared to a formulation that is not a controlled-release otic formulation

This dual action helps control excessive inflammatory responses, preventing chronic inflammation and tissue damage

This ratio provides a manageable volume of liquid that is not too large for a single injection site

So that you always know what to expect from your primary care clinic

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