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In the pancreas, they enhance glucose-dependent insulin secretion and suppress glucagon release, improving blood sugar control with a low risk of hypoglycemia when used alone (though risk increases when combined with insulin or sulfonylureas)

Weight-related comorbidities occur when serious medical conditions develop due to weight

stopping: Instead of stopping abruptly, some providers may recommend gradually reducing the dose to help manage the return of hunger and support a smoother transition

Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8

Guo J, Huan T