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Leone et al., 2019

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As such the overall impact of the manuscript would benefit greatly by detailed editing and potential re-organization. Response: As per your suggestion, we have replaced the section on requirements and detection of dimers with a reference to the original IUPHAR publication

Managing the Transition: Medical Supervision and Lifestyle Strategies If discontinuation is unavoidable, medical supervision during the transition reduces symptom severity and supports metabolic adjustment

Red light therapy is widely considered safe for the eyes when used correctly with a high-quality, FDA-cleared device