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In clinical trials, 100% of healthy volunteers experienced this chromaturia with administration of 5g hydroxocobalamin with other common effects including erythema, rash (predominantly acneiform appearance) and increased blood pressure

But it is necessary for proper research

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Paraesthesia (pins and needles) in the hands and feet often improves within two to four weeks, though complete resolution may take several months

The amount of diluent, the type of diluent, and even the technique you use to introduce it can dramatically impact the outcome