SAM, SAH and the SAM/SAH ratio SAM reflects methyl-donor capacity, while SAH inhibits methylation
Lets dive in: Glutathione (GSH) is a bio-chemical the body creates to protect itself from oxidation, aka, stress on a cellular level
You may have heard some unsavory things about how cosmetic companies hawked glutathionea powerhouse antioxidantas a skin lightening agent targeted at communities of color
Patients struggling with depression, autism, anxiety, or treatment resistance are frequently told to check their MTHFR, often with the implication that a single genetic result will explain their symptoms
381,382 Furthermore, by inhibiting NMDARs, ketamine can reduce the excitation of specific cortical GABAergic interneurons, resulting in a temporary increase in glutamate release that stimulates postsynaptic AMPA glutamate receptors