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And Lilly's other weight loss drug, tirzepatide, was shown to reduce body weight, on average, by 22.5% on average, or about 52 pounds, after 72 weeks

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However, from clinical studies alone, it is difficult to know how much of the benefit is due to direct effects in the joint and how much may be explained by weight loss or broader metabolic changes. That is why we wanted to address a basic mechanistic question first: whether GLP-1 is actually present in the joint environment

As a key nutrient in early pregnancy, vitamin B12 is an important substance involved in one-carbon metabolism, DNA methylation and cell metabolism [1, 2]

or for other reasons are at particularly high risk of negative consequences from misinterpreted UDS results