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Vitex agnus-castus (chasteberry) is promoted for progesterone support, but its proposed mechanism of acting on pituitary dopamine receptors to increase luteinizing hormone has not translated into clinically meaningful progesterone elevation in controlled studies, despite popularity in integrative medicine circles

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Improvements in symptoms can be expected within 2 weeks but may take up to three months, especially for diet-related deficiencies

Shahreyar M, Fahhoum R, Akinseye O, Bhandari S, Dang G, Khouzam RN