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The critical caveat: those trials used branded, FDA-approved products at standardized doses

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oral formulation 2019), and tirzepatide (2022)the latter being a dual GIP/GLP-1 agonist ( Table 2 ) (46)

Earlier framings of "0.34 partial agonist at GCGR" or "0.4 softened agonist at GLP-1R" mistook potency ratios (EC50_LY EC50_native) for efficacy multipliers (E_max_LY E_max_native) and are retracted