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A separate retrospective study published in 2025 in JAMA Ophthalmology compared patients who took either oral or subcutaneous semaglutide for type 2 diabetes and matched them to control based on race, sex, A1c and comorbid conditions such as DR, sleep apnea, hypertension and hyperlipidemia

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She also encourages patients to talk with their doctor about weighing the benefits of weight loss against the risk to their bones

The move from injectables to solid oral dose reflects a broader shift toward medicines that are easier to use, easier to scale and better suited to long-term patient needs

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