Low libido plus fatigue with a total testosterone under 300 ng/dL (10.4 nmol/L) confirmed on two separate morning blood tests
[DOI] [PubMed] [Google Scholar] 273.Lee SJ, Park SY, Jung MY, Bae SM, Kim IS
Manzano PCVJ, Ocampo MB, Ocampo LC, Maylem ERS, Lazaro JV
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They demonstrated that losing weight may have a greater impact on androgens compared to improving glycemic control, particularly in the groups with liraglutide and dulaglutide, and with dapaglifozin ( Although in healthy subjects the acute effect of GLP-1 infusion has led to contradictory results ( Studies using a high-fat diet (HFD) induced obesity mice model characterized by decreased serum T levels, impaired sperm quality, and increased testis inflammation, showed that exenatide administration was able to reduce body weight and improve the quality of sperm without increasing serum T levels but lowering the expression of proinflammatory cytokines ( Overall, these data support the use of GLP1-RAs in functional hypogonadism in the context of obesity or T2DM
