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The gap between doing it right and doing it wrong comes down to three things most guides never mention: temperature stability post-reconstitution, container selection for oxidation prevention, and the 28-day degradation curve that determines actual usable shelf life

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Those who choose to use it end up being the guinea pigs

Considerations: Proper spray technique (appropriate angle, avoiding the septum) Alternating nostrils per dose Using a saline rinse periodically to support nasal mucosal health Discontinuation and route change if persistent irritation develops Patients with allergic rhinitis, chronic sinusitis, or significant septal deviation may be poor candidates for nasal delivery and should be considered for injection or oral spray instead

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