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For the Immunometabolic panel, targets were allocated to specific heavy-metal isotopes following the sensitivity of the mass cytometer (e.g., placing lower abundance targets on higher sensitivity channels) and to avoid potential spillover, as previously outlined 92

Clinicians may delay dose escalation, maintain a current dose longer than 4 weeks, return to a previously tolerated dose, or temporarily interrupt treatment if patients experience significant side effects

NishimuraESHishikawaANakamichiRAkashioRChikumaSHashiguchiAet alDNA damage in proximal tubules triggers systemic metabolic dysfunction through epigenetically altered macrophages