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For sphere-size quantification, ImageJ was used to measure the area of the formed sphere

Sometimes this is caused by antibiotics, maldigestion, or starchy foods

Yoo C, Xing D, Gonzalez D, Jenkins V, Nottingham K, Dickerson B et al (2021) Acute Paraxanthine Ingestion improves cognition and short-term memory and helps sustain attention in a Double-Blind, Placebo-Controlled, crossover trial

And while its best known as a reproductive hormone, estrogen also plays a key role in maintaining joint health, in part because it helps regulate collagen production