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Initial applications favored topical and local repair

The GRK2 knockout is embryonic lethal, whereas GRK3 knockout mice are viable (Peppel et al., 1997), and homozygous GRK3 / mice show reduced analgesic tolerance to some opioid agonists in certain assay paradigms (Terman et al., 2004

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On this basis, this review comprehensively examines the role of ferroptosis in NDDs and explores the mechanisms through which exercise modulates ferroptosis to alleviate NDD pathology, thereby providing a scientific foundation for exercise-based brain health interventions