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Future research should prioritize biomarker-driven precision medicine approaches, enabling individualized therapy selection and development of agents that concurrently target ferroptosis and inflammation

Each component contributes through a distinct mechanism, providing researchers with a comprehensive model for studying how connective tissue physiology, epithelial biology, angiogenic signaling, and inflammatory pathways interact to maintain normal tissue function

Current Atheroscler Rep 2020

Low levels of B12 can lead to hyperpigmentation, vitiligo, pale or jaundiced skin, and premature signs of aging like fine lines and wrinkles