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95% CI, 1.99) and albiglutide (ROR, 0.60
30.3% at 104 weeks in a BMI 35 extension cohort TRANSCEND-T2D-1 confirmed (topline March 2026, published June 2026): First completed diabetes-specific Phase 3 trial -2.0% HbA1c and 16.8% weight loss in 537 patients, a separate program from TRIUMPH NDA timeline unchanged: industry estimates continue to expect Q4 2026 filing, based on standard practice following TRIUMPH-1's primary readout OSA data confirmed (ADA June 6, 2026): TRIUMPH-1's nested sleep apnea substudy showed 60.6% AHI reduction from a severe-OSA baseline of 58.6 events/hour This page updates after every trial announcement bookmark for the latest Introduction Retatrutide stands at the forefront of obesity medicine a first-in-class triple hormone agonist that has demonstrated some of the highest weight loss efficacy ever recorded in clinical trials
The FDA removed boxed warnings on HRT products last year, citing evolving evidence on safety and newer delivery methods
Clinical Data Clinical Trial Results 28.7% Average Weight Loss 68 weeks 58.6% Achieved 25%+ Loss of participants 445 Trial Participants Phase 3 Data from the Phase 3 TRIUMPH-4 trial of retatrutide, reported by Eli Lilly (topline, 2025)
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