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J Clin Invest (2011) 121:172232

10.1176/appi.ajp.162.2.394 179

Won Hee, J

COPD results in significant airway narrowing with reduction in airflow in the bronchioles and air-trapping in lungs it also causes fibrotic remodelling of the airways results in persist bronchoconstriction causing increased airway resistance, extensive alveolar and bronchiolar epithelial cells and pulmonary capillary apoptosis, emphysema and decreased surface area of alveoli for gaseous exchange and ventilation-circulation mismatch (V/Q) (Messineo et al

Science 293, 10891093