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Research employing PET tracers targeting the mitochondrial translocator protein (TSPO), such as [ 8 F]DPA-714, has demonstrated that some PCC patients continue to exhibit widespread elevated TSPO signals in the brain up to two years post-infection, with the intensity of this increase being most pronounced in individuals with persistent fatigue and cognitive symptoms (147) Animal studies have further substantiated that the sustained elevation of TSPO-PET signals (lasting at least 50 days) following SARS-CoV-2 infection arises from the co-activation of microglia, astrocytes, and endothelial cells, and that this neuroinflammatory state can endure long after viral clearance in the peripheral tissues (154)

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Am J Physiol 1963;204:64952.ArticlePubMed 5