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343 In the 2018 ACG position paper, the use of 5-ASAs, based on low quality of evidence, was weakly recommended against for overall symptom management in IBS

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[Target Other Skin Concerns] Have additional skin issues like signs of aging or redness

This happens because it helps your body use glucose more effectively [31]

Patients on this protocol who also use metabolic support agents like Metformin should note that both agents activate AMPK, and physician oversight is warranted to avoid compounding effects on blood glucose that could theoretically cause hypoglycemia in susceptible individuals, though this has not been reported clinically with MOTS-c at standard doses