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However, we cannot exclude other factors such as diet-induced weight loss, as a control-group was not included

doi: 10.1097/MCC.0000000000001294 40

This suggests that adipose tissue controls glucose metabolism in other metabolic tissues and implicates secreted factors, genetic materials, and metabolites such as free fatty acids

Study A matched participants 1:1 to receive either placebo or bremelanotide subcutaneously three times daily for 15 days (1.25 mg/1.00 mg/1.00 mg on day 1 and 2.5 mg/2.0 mg/2.0 mg on following days), and Study B assigned participants to receive either once-a-day (2.5 mg) or twice-a-day (2.5 mg/2.0 mg) doses of bremelanotide versus placebo for four days

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