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Guais, A., Baronzio, G., Sanders, E., Campion, F., Mainini, C., Fiorentini, G., Montagnani, F., Behzadi, M., Schwartz, L., and Abolhassani, M

This is the direct-repair option, and the one researchers reach for when they want to skip the pituitary step

Dose escalation typically produces additional weight loss, but the benefit diminishes at higher doses and varies by individual

For example, FTO rs9939609 carriers may have higher baseline appetite signaling, suggesting that standard doses might require monitoring or adjustment to achieve target appetite reduction

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