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PPIs and SIBO Small intestinal bacterial overgrowth (SIBO) commonly occurs in patients on omeprazole (PPI) and in atrophic gastritis (a condition leading to very low stomach acid).[183] SIBOoccurs significantly more frequently among long term PPI users than patients with IBS or control subjects.[184] Considering that low stomach acid is an important risk factor for the development of SIBO, recent research has focused on the mechanism by which PPIs lead to SIBO

Regulates Circadian Rhythms Helps balance natural sleep-wake cycles