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22 Reduced porin expression significantly limits their uptake, which leads to resistance against these drugs

Sirtori CR, Calabresi L, Franceschini G, Baldassarre D, Amato M, Johansson J, Salvetti M, Monteduro C, Zulli R, Muiesan ML, Agabiti-Rosei E

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Key issues include the need for mechanistic validation in human models, optimizing localized delivery to enhance retinal bioavailability, and ensuring long-term safety