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Igf-1r activation is reported to suppress inflammation in the TME of NSCLC models 39 and induce degradation of retinoic acid-inducible gene-I (RIG1), a pattern-recognition receptor required for type 1 IFN production and the proper function of the innate immune response 40

These adverse effects are probably caused by the drugs themselves rather than by extraneous factors, as indicated by the results consistency across several studies and low degree of heterogeneity

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Method performance depends on preserving the redox state present at collection, selectively detecting both analytes, controlling matrix effects, and validating quantitative performance across the expected concentration range

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