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It encodes MOTS-c, a 16-amino-acid peptide that travels from the mitochondrial matrix into the nucleus and even into the bloodstream, acting less like a local signaling molecule and more like a systemic hormone

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These changes in brain function have also been linked to age-associated variations in cognitive function

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Overall, current data substantiates a strong mechanistic rationale and an early clinical signal for natural compounds in ASD, especially in subgroups with oxidative or mitochondrial dysfunction or nutritional deficits