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Quick Answer: Tirzepatide may reduce absorption of oral birth control pills due to delayed gastric emptying, prompting FDA recommendations for backup contraception during initial treatment and dose escalations

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In the SURPASS-2 study, the three doses of tirzepatide (5, 10, and 15 mg once weekly) were tested with the GLP-1RA semaglutide (1 mg once weekly) as a comparator in patients not optimally controlled on monotherapy with metformin (71)