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Second, there is concern regarding the potential for mood-related side effects

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Given that follistatin counteracts the fibrogenic effects of activin A, which is linked to hepatic inflammation, fibrosis, and metabolic dysregulation, the observed rise in follistatin and fall in activin A represent a protective shift toward better inflammatory balance and hepatocellular function

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Crucially, this deficiency strongly correlated with the severity of the patients' fatigue, autonomic dysfunction, and neurocognitive symptoms