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One is an old friend, orforglipron, but new trial data this time

While Resmetirom, a thyroid hormone receptor- agonist, received FDA approval in 2024 for treating non-cirrhotic metabolic dysfunction-associated steatohepatitis (MASH) with moderate-to-severe fibrosis, its application is restricted to specific patient subsets, leaving a substantial treatment gap for early-stage disease and broader patient populations (Harrison et al., 2024)

Converting biology into clinical benefit: lessons learned from BRAF inhibitors

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AC treatment significantly reduced neurological deficit scores and delayed disease onset