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However, the LMNA (A539V) fish without tails were unable to produce viable offspring and died at 4 months

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Takahashi K, Wang F, Morita K, Yan Y, Patel K, Bueso-Ramos CE, Gumbs C, Zhang J, Kornblau S, DiNardo CD, Ravandi F, Garcia-Manero G, Jabbour EJ, Andreeff M , Kantarjian HM, Konopleva M, Futreal A

Overdosing wastes money without proportionally improving results, since receptor saturation means diminishing returns beyond optimal doses